How Cetuem Myo-Gel Works
The pain-relieving mechanism of action of menthol results from a counter-irritant effect. This has the effect of overriding the pain signals travelling to the brain through a process modulated between pain-transmitting and non-pain transmitting neurons.This process, known as “gate control” or “gating,” was first described by Melzak and Wall. Find out more on You Tube – See how effective the use of myogel ice pack is with ultrasound
Pain is Perceived
Gate control theory is based on the understanding that pain is transmitted by two kinds of afferent nerve fibers. One is the larger myelinated A-delta fiber, which carries quick, intense-pain messages. The other is the smaller, unmyelinated “C” fiber, which transmits throbbing, chronic pain. A third type of nerve fiber, called A-beta, is “nonnociceptive,” meaning it does not transmit pain stimuli. The gate control theory says that signals transmitted by the A-delta and C pain fibers can be halted by the activation or stimulation of the nonnociceptive A-beta fibers and thus stop an individual’s perception of pain.
Pain is NOT Perceived
In recent tests, laboratory researchers have discovered that menthol stimulates the TRPM8 cold receptors. Even though it has been accepted for a long time that cooling and cold can induce analgesia it has been a poorly understood mechanism. Researchers have continued to isolate these specific heat-sensitive transient receptor potential (TRP) channels within our sensory neurons and we are now able to have a much better understanding of the body’s cutaneous temperature detection. With the isolation and further study of these specific TRPM8 receptors there is stronger evidence supporting the benefits achieved with the cooling effect of menthol in functioning as a topical analgesic while activating these receptors and the resulting pain relief.
Read the Research
Preliminary MyoGel Analysis by Professor Tim Watson
University of Hertfordshire